Inactive C8A-humanin analog is as stable as a potent S14G-humanin analog
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چکیده
منابع مشابه
Alzheimer's disease (AD)-linked mutant amyloid precursor protein (5). A gene coding for HN was identified in a cDNA library derived from the occipital lobe of a brain from a patient with AD (5). HN is a 24-amino acid residue peptide
We have previously shown that the structural stability of humanin (HN), a neuroprotective peptide ligand, is one of the attributes to the observed activity differences between HN analogs. It has been observed that the activity increased consecutively in the S7A-HN analog, the parent HN and the S14G-HN analog, consistent with the increased stability observed in that order. In the present study, ...
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BACKGROUND AND PURPOSE Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on focal cerebral ischemia/reperfusion injury in mice. METHODS Mice underwent middle cerebral artery occlusion for 75 minutes followed by 24-hour reper...
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Mitochondrial RNR-2 (mt-RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical s...
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Humanin (HN) is a newly discovered 24-amino acid peptide, which may suppress neuronal cell death. HN cDNA includes the open reading frame (HN-ORF) of 75 bases, located 950 bases downstream of the 5' end of the HN cDNA. It was demonstrated that HN cDNA is 99% identical with mitochondrial DNA (mtDNA) sequence. HN homologues have been identified as expressed sequence tags (ESTs) in rat and nematod...
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Analog neural networks with feedback can be used to implement l(Winner-Take-All (KWTA) networks. In turn, KWTA networks can be used as decoders of a class of nonlinear error-correcting codes. By interconnecting such KWTA networks, we can construct decoders capable of decoding more powerful codes. We consider several families of interconnected KWTA networks, analyze their performance in terms of...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2013
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2013.1797